Five-term Rep. Scott Tipton (R-CO), who was backed by President Donald Trump, lost his primary to Lauren Boebert, the owner of Shooters Grill in Colorado.
The primary serves as another primary loss for Trump, who had endorsed Tipton over Boebert.
Mitsch Bush lost to Tipton during the 2018 midterm elections.
Conservative outsider Bob Good unseated Rep. Denver Riggleman (R-VA) in June despite the House Freedom Caucus backing Riggleman over Good.
Conservative millennial Madison Cawthorn then defeated Lynda Bennet, who was endorsed by the House Freedom Fund, the Senate Conservative Fund, the American Conservative Union (ACU), and other influential D.C. conservatives.