The disturbing incident unfolded in Markham, Illinois, a suburb south of Chicago.
The family welcomed their son visiting from Kentucky a few days before Tuesday when they called the police, according to a report from WLT-TV.
The man had arrived with several duffel bags, but the family thought it was strange that he kept asking for clothing, but never unpacked his bags.
When the son left the home to visit the local Markham Public Library on Tuesday, a family members saw their opportunity to look into the bags and to their horror, they discovered severed human body parts.
The family said that the man had ridden the Greyhound Bus from Kentucky to Chicago with the severed body parts allegedly in his duffel bags for the five hour trip.